Mechanism of Infectious Disease

32 yr old general labor, fell ill shortly after working on a job digging up old water pipes. He worked around shallow pools of stagnant water. 10 days after the contract ended he developed fever and aching muscles. He also had nausea, vomiting, and diarrhea. He went to the doctor, after hearing the man’s story the doctor suspected West Nile fever and ordered serological testing. The man went home to recover, feeling better by the end of the week.

1. The doctor ordered serological testing. How would antibody titers assist the doctor in confirming the diagnosis?

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2. When the man was feeling his worst, he had extreme malaise, vomiting, and diarrhea. What stage of the illness was he experiencing at that time? What are the physiological mechanisms that give rise to the signs and symptoms of the infectious illness?

3. West Nile virus has a single – stranded RNA genome. How does the virus replicate? In general terms, what are the various effects viruses can have on the host cells?

Questions should be answered in a 4 page paper, using current APA format with at least 3 sources: journals, textbooks, evidence-based websites. Sources must have been written in the last 5 years. NO .com, Wikipedia, or up-to-date, etc for sources.

Need by Tuesday November 1

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